Matthias Gaestel

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Matthias Gaestel is currently a director of the Institute for Physiological Chemistry at the Hannover Medical School. Matthias Gaestel received his PhD in Biology (Biophysics) from the Humboldt-University, Berlin in 1983. During postdoctoral training, he characterised growth-related heat shock proteins at the Central Institute for Molecular Biology, Berlin, and analysed translational control of gene expression in the laboratory of George Brawerman at Tufts University, Boston. Matthias Gaestel achieved his habilitation in Biochemistry from Free University Berlin in 1993. He was a Junior Research Group Leader at the Max-Delbrück-Centrum for Molecular Medicine (MDC), Berlin-Buch from 1991 to 1995. Since 2001, he is also a full professor and chair of biochemistry at the Hannover Medical School.


Contents

Research

At the moment, his research interest is focused on regulation of gene expression by protein phosphorylation at the post-transcriptional level as well as on function of the new ERK3/MK5 signaling module. Mathhias Gaestel is also interested in analysis of mechanisms of stress-dependent signal transduction and nucleo-cytoplasmic signaling.

Awards

  • Gerhard-Domagk-Prize for Cancer Research together with Heinz Bielka and Rainer Benndorf in 1993.

Selected Publications

  • Schumacher S, Laass K, Kant S, Shi Y, Visel A, Gruber AD, Kotlyarov A, Gaestel M. Scaffolding by ERK3 regulates MK5 in development. EMBO J. 2004 Dec 8;23(24):4770-9. Epub 2004 Nov 11. PubMed PMID: 15538386
  • Gaestel M. MAPKAP kinases - MKs - two's company, three's a crowd. Nat Rev Mol Cell Biol. 2006 Feb;7(2):120-30. PubMed PMID: 16421520
  • Hitti E, Iakovleva T, Brook M, Deppenmeier S, Gruber AD, Radzioch D, Clark AR, Blackshear PJ, Kotlyarov A, Gaestel M. Mitogen-activated protein kinase-activated protein kinase 2 regulates tumor necrosis factor mRNA stability and translation mainly by altering tristetraprolin expression, stability, and binding to adenine/uridine-rich element. Mol Cell Biol. 2006 Mar;26(6):2399-407. PubMed PMID: 16508014
  • Vertii A, Hakim C, Kotlyarov A, Gaestel M. Analysis of properties of small heat shock protein Hsp25 in MAPK-activated protein kinase 2 (MK2)-deficient cells: MK2-dependent insolubilization of Hsp25 oligomers correlates with susceptibility to stress. J Biol Chem. 2006 Sep 15;281(37):26966-75. Epub 2006 Jul 13. PubMed PMID: 16840785
  • Jakobs A, Koehnke J, Himstedt F, Funk M, Korn B, Gaestel M, Niedenthal R. Ubc9 fusion-directed SUMOylation (UFDS): a method to analyze function of protein SUMOylation. Nat Methods. 2007 Mar;4(3):245-50. Epub 2007 Feb 4. PubMed PMID: 17277783
  • Zaru R, Ronkina N, Gaestel M, Arthur JS, Watts C. The MAPK-activated kinase Rsk controls an acute Toll-like receptor signaling response in dendritic cells and is activated through two distinct pathways. Nat Immunol. 2007 Nov;8(11):1227-35. Epub 2007 Sep 30. PubMed PMID: 17906627

Reference

  • Schumacher S, Laass K, Kant S, Shi Y, Visel A, Gruber AD, Kotlyarov A, Gaestel M. Scaffolding by ERK3 regulates MK5 in development. EMBO J. 2004 Dec 8;23(24):4770-9. Epub 2004 Nov 11. PubMed PMID: 15538386

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