Lee M. Graves

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Lee M. Graves is currently the faculty director of the UNC Michael Hooker Proteomics Core Facility and an Associate Professor at the Department of Pharmacology, University of NC at Chapel Hill, Chapel Hill, NC. Lee M. Graves received his B.S. in Biochemistry from Iowa State University, Ames, IA and his Ph.D. in Biochemistry from University of Illinois, Urbana, IL. Lee M. Graves joined the group of the late Prof. Edwin G. Krebs, Nobel Price Laureate at Washington University, Seattle, as a post doctoral fellow.

Contents

Research

The overall objective of Lee M. Graves's research is to study dysregulation of protein kinases in disease. This includes applying methods of purifying and identifying kinase activity “signatures” en masse by quantitative mass spectrometry and mapping post-translational modifications. This includes applying novel technologies such as kinase inhibitor bead (KIBs) affinity chromatography, studying protein- protein interactions, titanium and phosphotyrosine peptide capture and methods of ITRAQ/SILAC quantitative mass spectrometry.

Awards

  • 1992 American Diabetes Association Fellowship Award - University of Washington
  • 2000 Jefferson-Pilot Research Award - University of North Carolina
  • 2000 American Heart Association Established Investigator Award - Univ. of North Carolina
  • 2006 PHRMA Sabbatical Fellowship Award-Univ of North Carolina
  • 2007 University of Sydney International Research Fellowship

Selected Publications

  • Zawistowski JS, Graves LM, Johnson GL. Assessing adaptation of the cancer kinome in response to targeted therapies. Biochem Soc Trans. 2014 Aug;42(4):765-9. doi: 10.1042/BST20130274. PubMed PMID: 25109955
  • Johnson GL, Stuhlmiller TJ, Angus SP, Zawistowski JS, Graves LM. Molecular pathways: adaptive kinome reprogramming in response to targeted inhibition of the BRAF-MEK-ERK pathway in cancer. Clin Cancer Res. 2014 May 15;20(10):2516-22. doi: 10.1158/1078-0432.CCR-13-1081. Epub 2014 Mar 24. PubMed PMID: 24664307
  • Cooper MJ, Cox NJ, Zimmerman EI, Dewar BJ, Duncan JS, Whittle MC, Nguyen TA, Jones LS, Ghose Roy S, Smalley DM, Kuan PF, Richards KL, Christopherson RI, Jin J, Frye SV, Johnson GL, Baldwin AS, Graves LM. Application of multiplexed kinase inhibitor beads to study kinome adaptations in drug-resistant leukemia. PLoS One. 2013 Jun 24;8(6):e66755. doi: 10.1371/journal.pone.0066755. Print 2013. PubMed PMID: 23826126
  • Graves LM, Duncan JS, Whittle MC, Johnson GL. The dynamic nature of the kinome. Graves LM, Duncan JS, Whittle MC, Johnson GL. Biochem J. 2013 Feb 15;450(1):1-8. doi: 10.1042/BJ20121456. PubMed PMID: 23343193

Reference

  • Zawistowski JS, Graves LM, Johnson GL. Assessing adaptation of the cancer kinome in response to targeted therapies. Biochem Soc Trans. 2014 Aug;42(4):765-9. doi: 10.1042/BST20130274. PubMed PMID: 25109955
  • Graves LM, Duncan JS, Whittle MC, Johnson GL. The dynamic nature of the kinome. Graves LM, Duncan JS, Whittle MC, Johnson GL. Biochem J. 2013 Feb 15;450(1):1-8. doi: 10.1042/BJ20121456. PubMed PMID: 23343193

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