L. Bryan Ray

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L. Bryan Ray has worked as an editor at "Science" journal for over 20 years. He currently a Senior Editor at "Science" and was the Founding Editor of "Science Signaling". Bryan got his undergraduate degree at the University of California, Berkeley, and his PhD from the University of Virginia.

Contents

Research

In 1987, working as a postdoc of Dr. Thomas W. Sturgill,Bryan discovered a novel serine-threonine kinase, which after being stimulated with insulin phosphorylated microtubule-associated protein 2 [1]. The kinase was named microtubule-associated protein kinase (MAP kinase) to indicate that fact. The same abbreviation has been changed to mitogen-activated protein kinase when it became known that a plethora of mitogens are major activators of MAP kinases, and that they phosphorylate many diverse downstream targets, not just microtubule-associated protein [2][3][4]. Now, working for "Science", he handles papers on topics that include signal transduction, systems biology, protein and gene networks, cell cycle, apoptosis, metabolism, circadian rhythms, and aging.

Selected Publications

  • Ray LB. Cell signaling. Getting your loops straight. Introduction. Science. 2008 Oct 17;322(5900):389. doi: 10.1126/science.322.5900.389. PubMed PMID: 18927382
  • Gough NR, Adler EM, Ray LB. Cell signaling: from beginning to end. Sci STKE. 2005 Oct 11;2005(305):eg9. PubMed PMID:16219904
  • Ray LB. The science of signal transduction. Introduction. Science. 1999 Apr 30;284(5415):755-6. PubMed PMID: 10336400
  • Sturgill TW, Ray LB, Anderson NG, Erickson AK. Purification of mitogen-activated protein kinase from epidermal growth factor-treated 3T3-L1 fibroblasts. Methods Enzymol. 1991;200:342-51. PubMed PMID: 1720187
  • Erickson AK, Ray LB, Sturgill TW. Microtubule-associated protein 1A is the fibroblast HMW MAP undergoing mitogen-stimulated serine phosphorylation. Biochem Biophys Res Commun. 1990 Jan 30;166(2):827-32. PubMed PMID: 2405857
  • Ray LB, Sturgill TW. Characterization of insulin-stimulated microtubule-associated protein kinase. Rapid isolation and stabilization of a novel serine/threonine kinase from 3T3-L1 cells. J Biol Chem. 1988 Sep 5;263(25):12721-7. PubMed PMID: 2842341
  • Sturgill TW, Ray LB, Erikson E, Maller JL. Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II. Nature. 1988 Aug 25;334(6184):715-8. PubMed PMID: 2842685
  • Ray LB, Sturgill TW. Insulin-stimulated microtubule-associated protein kinase is phosphorylated on tyrosine and threonine in vivo. Proc Natl Acad Sci U S A.1988 Jun;85(11):3753-7. PubMed PMID: 3287375; PubMed Central PMCID: PMC280296
  • Ray LB, Sturgill TW. Rapid stimulation by insulin of a serine/threonine kinase in 3T3-L1 adipocytes that phosphorylates microtubule-associated protein 2 in vitro. Proc Natl Acad Sci U S A. 1987 Mar;84(6):1502-6. PubMed PMID:2951732; PubMed Central PMCID: PMC304462

References

  • 1.Ray LB, Sturgill TW. Rapid stimulation by insulin of a serine/threonine kinase in 3T3-L1 adipocytes that phosphorylates microtubule-associated protein 2 in vitro. Proc Natl Acad Sci U S A. 1987 Mar;84(6):1502-6. PubMed PMID:2951732; PubMed Central PMCID: PMC304462
  • 2.Eblen ST, Kumar NV, Shah K, Henderson MJ, Watts CK, Shokat KM, Weber MJ. Identification of novel ERK2 substrates through use of an engineered kinase and ATP analogs. J Biol Chem. 2003 Apr 25;278(17):14926-35. Epub 2003 Feb 19. PubMed PMID: 12594221
  • 3.Carlson SM, Chouinard CR, Labadorf A, Lam CJ, Schmelzle K, Fraenkel E, White FM. Large-scale discovery of ERK2 substrates identifies ERK-mediated transcriptional regulation by ETV3. Sci Signal. 2011 Oct 25;4(196):rs11. doi: 10.1126/scisignal.2002010. PubMed PMID: PMID:22028470; PubMed Central PMCID:PMC3779841.
  • 4.Courcelles M, Frémin C, Voisin L, Lemieux S, Meloche S, Thibault P. Phosphoproteome dynamics reveal novel ERK1/2 MAP kinase substrates with broad spectrum of functions. Mol Syst Biol. 2013 May 28;9:669. doi:10.1038/msb.2013.25. PubMed PMID:23712012

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