John Brognard

From MAP Kinase Wiki
Jump to: navigation, search

John Brognard is currently a group leader at Cancer Research UK Manchester Institute. He received his BSc degree in Chemistry from James Madison University (Harrisonburg, Virginia) followed by a MSc degree in biotechnology from John Hopkins University (Baltimore, Maryland). He then joined Dr. Phillip Dennis's laboratory at the National Cancer Institute in Bethesda, Maryland. John Brognard obtained his PhD from University of California, San Diego in Dr. Alexandra Newton's laboratory. Lastly, John trained as a postdoctoral fellow in Dr.. Tony Hunter's laboratory at the Salk Institute. He joined the Cancer Research UK Manchester Institute as a group leader in September of 2010.

Contents

Research

John Brognard is a co-discoverer of signaling pathways that promote resistance to chemotherapy and mechanisms implicated in the initial stages of lung tumorigenesis. Furthermore, Brognard investigates molecular basis behind smoking and lung cancer cell proliferation. John Brognard is also well known for discovering a novel class of phosphatases (PHLPP1 and PHLPP2) that act directly on Akt and PKC to decrease signaling through these pathways.

Selected publications

  • Brognard J, Hunter T. Protein kinase signaling networks in cancer. Curr Opin Genet Dev. 2011 Feb;21(1):4-11. doi: 10.1016/j.gde.2010.10.012. Epub 2010 Nov 29. PubMed PMID: 21123047
  • Brognard J, Newton AC. PHLiPPing the switch on Akt and protein kinase C signaling. Trends Endocrinol Metab. 2008 Aug;19(6):223-30. doi: 10.1016/j.tem.2008.04.001. Epub 2008 May 27. PubMed PMID: 18511290
  • Brognard J, Sierecki E, Gao T, Newton AC. PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms. Mol Cell. 2007 Mar 23;25(6):917-31. PubMed PMID: 17386267

References

  • Brognard J, Sierecki E, Gao T, Newton AC. PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms. Mol Cell. 2007 Mar 23;25(6):917-31. PubMed PMID: 17386267
  • Tsurutani J, Castillo SS, Brognard J, Granville CA, Zhang C, Gills JJ, Sayyah J, Dennis PA. Tobacco components stimulate Akt-dependent proliferation and NFkappaB-dependent survival in lung cancer cells. Carcinogenesis. 2005 Jul;26(7):1182-95. Epub 2005 Mar 24. PubMed PMID: 15790591

External sites

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox