Jim Woodgett

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Jim Woodgett is Investigator and Director of Research of the Lunenfeld-Tanenbaum Research Institute at the University of Toronto, Canada. He got his PhD at the University of Dundee, UK, where he had been working in a lab of Dr. Philip Cohen.

Contents

Research

Dr. Woodgett's lab is interested in cell signaling involved in breast cancer, colorectal cancer, diabetes, Alzheimer Disease and bipolar disorder. Research mostly focuses on JNK and p38 MAP kinases, WNT signaling and PI3K-Akt signaling pathways. Back in early 90-ies, Jim Woogett's group was one of the first to discover JNK kinase [1][2]

Selected Publications

  • Preston TJ, Woodgett JR, Singh G. JNK1 activity lowers the cellular production of H2O2 and modulates the growth arrest response to scavenging of H2O2 by catalase. Exp Cell Res. 2003 Apr 15;285(1):146-58. PubMed PMID:12681294
  • Kiefer F, Tibbles LA, Lassam N, Zanke B, Iscove N, Woodgett JR. Novel components of mammalian stress-activated protein kinase cascades. Biochem Soc Trans. 1997 May;25(2):491-8. Review. PubMed PMID: 9191142
  • Gutstein HB, Rubie EA, Mansour A, Akil H, Woodgett JR. Opioid effects on mitogen-activated protein kinase signaling cascades. Anesthesiology. 1997 Nov;87(5):1118-26. PubMed PMID: 9366464
  • Tibbles LA, Woodgett JR. The stress-activated protein kinase pathways. Cell Mol Life Sci. 1999 Aug 15;55(10):1230-54. Review. PubMed PMID: 10487205
  • Zanke BW, Rubie EA, Winnett E, Chan J, Randall S, Parsons M, Boudreau K, McInnis M, Yan M, Templeton DJ, Woodgett JR. Mammalian mitogen-activated protein kinase pathways are regulated through formation of specific kinase-activator complexes. J Biol Chem. 1996 Nov 22;271(47):29876-81. PubMed PMID: 8939929
  • Zanke BW, Boudreau K, Rubie E, Winnett E, Tibbles LA, Zon L, Kyriakis J, Liu FF, Woodgett JR. The stress-activated protein kinase pathway mediates cell death following injury induced by cis-platinum, UV irradiation or heat. Curr Biol. 1996 May 1;6(5):606-13. PubMed PMID: 8805279
  • Kyriakis JM, Banerjee P, Nikolakaki E, Dai T, Rubie EA, Ahmad MF, Avruch J, Woodgett JR. The stress-activated protein kinase subfamily of c-Jun kinases. Nature. 1994 May 12;369(6476):156-60. PubMed PMID: 8177321
  • Dai T, Rubie E, Franklin CC, Kraft A, Gillespie DA, Avruch J, Kyriakis JM,Woodgett JR. Stress-activated protein kinases bind directly to the delta domain of c-Jun in resting cells: implications for repression of c-Jun function. Oncogene. 1995 Mar 2;10(5):849-55. PubMed PMID: 7898927
  • Pulverer BJ, Hughes K, Franklin CC, Kraft AS, Leevers SJ, Woodgett JR. Co-purification of mitogen-activated protein kinases with phorbol ester-induced c-Jun kinase activity in U937 leukaemic cells. Oncogene. 1993 Feb;8(2):407-15. PubMed PMID: 8426747

References

  • 1.Kyriakis JM, Banerjee P, Nikolakaki E, Dai T, Rubie EA, Ahmad MF, Avruch J,Woodgett JR. The stress-activated protein kinase subfamily of c-Jun kinases.Nature. 1994 May 12;369(6476):156-60. PubMed PMID:8177321
  • 2.Kyriakis JM, Woodgett JR, Avruch J. The stress-activated protein kinases. A novel ERK subfamily responsive to cellular stress and inflammatory cytokines. Ann N Y Acad Sci. 1995 Sep 7;766:303-19. Review. PubMed PMID: 7486678

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