Latest MAP Kinase news

The Biochemistry, Biology and Pathology of MAP Kinases II, September 11-12, 2014, Vilnius, Lithuania

2013 April 15

It`s our pleasure to invite you to the international event "The Biochemistry, Biology and Pathology of MAP Kinases II". The conference is organized by Enterprise Lithuania together with Swiss Institute of Bioinformatics and Lithuanianian Biotechnology association. Register now and enjoy the exciting programme of "The Biochemistry, Biology and Pathology of MAP Kinases II"


Next-Gen Kinase Inhibitors Conference - Cambridge Healthtech Institute, June 17 - 19, 2013

2013 March 01

This established and well-recognized kinase conference addresses reoccurring questions about selectivity, safety, resistance and novelty. After many years of research and therapeutic developments of kinase inhibitors, the field still offers new opportunities as novel kinases and their inhibitors are making an appearance. In addition, interest in repurposing of already developed drugs is growing...


Control of the cell cycle progression by the MAPK Hog1

Josep Clotet, Joan Vendrell, Xavier Escote
2013 February 07

Eukaryotic cells coordinate various intracellular activities in response to environmental stresses, activating an adaptive program to maximize the probability of survival and proliferation. Cells transduce diverse cellular stimuli by multiple mitogen-activated protein kinase (MAPK) cascades. MAPK are key signal transduction kinases required to respond to stress. A prototypical member of the MAPK...


Ultrasensitive MAPK/Erk activation in absence of protein synthesis in Xenopus oocytes

2013 January 30

The mitogen-activated protein kinase (MAPK) cascade in Xenopus oocytes exhibits an all-or-none, ultrasensitive response, which is believed to result from a positive feed-back loop. Here we describe a context where 1,10-phenanthroline slowly, but strongly, activates MAPK while it impairs protein synthesis in a zincdependent manner, abolishing any feed-back loop. The induced-MAPK response was found...


Batsheva de Rothschild Seminar on Biochemistry, Biology and Pathology of MAP Kinases

Maale Hachamisha, Jerusalem Hills
2012 November 23

This abstract book contains most of the abstracts presented to the Batsheva de Rothschild Seminar on Biochemistry, Biology and Pathology of MAP Kinases. An Aharon Katzir-Katchalski Meeting and an Israel Science Foundation Conference, 14-18 October 2012, Maale Hachamisha, Jerusalem Hills, Israel.


Copenhagen Bioscience Conferences, December 2-5, 2012

2012 November 18

An exclusive three day conference featuring keynotes by 15 of the world's top scientists within protein research. Topics include: autophagy, DNA damage signaling, signaling systems and networks, metabolism and aging, cell cycle as well as epigenetics and cancer signaling.


Life Sciences Baltics 2012, September 12-14, 2012, Vilnius, Lithuania

2012 July 24

Conference and Seminars featuring world-class speakers and attendees will attract Nobel Prize winner, prominent experts, high level public officials, representatives from the leading associations and corporations operating within the global biotechnology sector, members of the Baltic life sciences community.


The Biochemistry, Biology and Pathology of MAP Kinases, Jerusalem, Israel, 14-18 October, 2012

2012 March 09

MAP Kinase cascades are evolutionary conserved, intracellular signal transduction pathways that respond to various extracellular stimuli and control a large number of fundamental cellular processes including growth, proliferation, differentiation, motility, stress response, survival and apoptosis. At present, four different mammalian MAP Kinase cascades have been identified, and named according...


Model of enzyme's structure could spur new therapies

David Orenstein
2011 November 03

Scientists have determined the structure of an enzyme complex that regulates vital cell functions. Disregulation of such complexes is associated with diseases such as cancer and Alzheimer's. The new work provides drug developers with a specific and unique new target to consider in their efforts to find new treatments.


The CDK inhibitors in cancer research and therapy

Jonas Cicenas and Mindaugas Valius
2011 August 11

Chemical compounds that interfere with an enzymatic function of kinases are useful for gaining insight into the complicated biochemical processes in mammalian cells. Cyclin-dependent kinases (CDK) play an essential role in the control of the cell cycle and/or proliferation. These kinases as well as their regulators are frequently deregulated in different human tumors. Aberrations in CDK activity...


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Latest MAP Kinase news

GGA3 Functions as a Switch to Promote Met Receptor Recycling, Essential for Sustained ERK and Cell Migration

Cells are dependent on correct sorting of activated receptor tyrosine kinases (RTKs) for the outcome of growth factor signaling. Upon activation, RTKs are coupled through the endocytic machinery for...

Gene regulation by MAPK substrate competition

Developing tissues are patterned by coordinated activities of signaling systems, which can be integrated by a regulatory region of a gene that binds multiple transcription factors or by a...

Axon regeneration requires coordinate activation of p38 and JNK MAPK pathways

Signaling pathways essential for axon regeneration, but not for neuron development or function, are particularly well suited targets for therapeutic intervention. We find that the parallel PMK-3(p38)...

MPK-1 ERK Controls Membrane Organization in C. elegans Oogenesis via a Sex-Determination Module.

Tissues that generate specialized cell types in a production line must coordinate developmental mechanisms with physiological demand, although how this occurs is largely unknown. In the...

The role of JNK in the development of hepatocellular carcinoma

The cJun NH(2)-terminal kinase (JNK) signal transduction pathway has been implicated in the growth of carcinogen-induced hepatocellular carcinoma. However, the mechanism that accounts for...


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