Erk1/2 Reviews

Plotnikov A, Zehorai E, Procaccia S, Seger R.The MAPK cascades: signaling components, nuclear roles and mechanisms of nuclear translocation. - Biochim Biophys Acta. 2011 Sep;1813(9):1619-33.

Steelman LS, Franklin RA, Abrams SL, Chappell W, Kempf CR, Bдsecke J, Stivala F, Donia M, Fagone P, Nicoletti F, Libra M, Ruvolo P, Ruvolo V, Evangelisti C, Martelli AM, McCubrey JA. Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy. - Leukemia. 2011 Jul;25(7):1080-94.

Mendoza MC, Er EE, Blenis J. The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation.. - Trends Biochem Sci. 2011 Jun;36(6):320-8.

Brzezianska E, Pastuszak-Lewandoska D. A minireview: the role of MAPK/ERK and PI3K/Akt pathways in thyroid follicular cell-derived neoplasm. - Front Biosci. 2011 Jan 1;16:422-39.

Calvo F, Agudo-Ibбсez L, Crespo P. The Ras-ERK pathway: understanding site-specific signaling provides hope of new anti-tumor therapies. - Bioessays. 2010 May;32(5):412-21..

Keshet Y, Seger R. The MAP kinase signaling cascades: a system of hundreds of components regulates a diverse array of physiological functions. - Methods Mol Biol. 2010;661:3-38

Zehorai E, Yao Z, Plotnikov A, Seger R.The subcellular localization of MEK and ERK--a novel nuclear translocation signal (NTS) paves a way to the nucleus. - Mol Cell Endocrinol. 2010 Jan 27;314(2):213-20

Martin P, Pognonec P. ERK and cell death: cadmium toxicity, sustained ERK activation and cell death. - FEBS J. 2010 Jan;277(1):39-46.

Teixeiro E, Daniels MA. ERK and cell death: ERK location and T cell selection.. - FEBS J. 2010 Jan;277(1):30-8.

Subramaniam S, Unsicker K. ERK and cell death: ERK location and T cell selection.. - FEBS J. 2010 Jan;277(1):22-9.

Cagnol S, Chambard JC. ERK and cell death: mechanisms of ERK-induced cell death--apoptosis, autophagy and senescence. - FEBS J. 2010 Jan;277(1):2-21.

Steelman LS, Abrams SL, Whelan J, Bertrand FE, Ludwig DE, Bдsecke J, Libra M, Stivala F, Milella M, Tafuri A, Lunghi P, Bonati A, Martelli AM, McCubrey JA. Contributions of the Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways to leukemia - Leukemia. 2008 Apr;22(4):686-707

Gold MR.B cell development: important work for ERK.- Immunity. 2008 Apr;28(4):499-508.

McCubrey JA, Steelman LS, Abrams SL, Bertrand FE, Ludwig DE, Bдsecke J, Libra M, Stivala F, Milella M, Tafuri A, Lunghi P, Bonati A, Martelli AM.Targeting survival cascades induced by activation of Ras/Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways for effective leukemia therapy.- Leukemia. 2008 Apr;22(4):708-22.

May LT, Hill SJ.ERK phosphorylation: spatial and temporal regulation by G protein-coupled receptors.- Int J Biochem Cell Biol. 2008;40(10):2013-7.

Yao Z, Seger R.The ERK signaling cascade--views from different subcellular compartments.- Biofactors. 2009 Sep-Oct;35(5):407-16.

Schmitz KJ, Lang H, Wohlschlaeger J, Sotiropoulos GC, Reis H, Schmid KW, Baba HA.AKT and ERK1/2 signaling in intrahepatic cholangiocarcinoma.- World J Gastroenterol. 2007 Dec 28;13(48):6470-7.

Zhai H, Li Y, Wang X, Lu L.Drug-induced alterations in the extracellular signal-regulated kinase (ERK) signalling pathway: implications for reinforcement and reinstatement.- Cell Mol Neurobiol. 2008 Feb;28(2):157-72.

Khavari TA, Rinn J.Ras/Erk MAPK signaling in epidermal homeostasis and neoplasia.- Cell Cycle. 2007 Dec 1;6(23):2928-31.

Cohen-Armon M. PARP-1 activation in the ERK signaling pathway.- 2007 Nov;28(11):556-60.

Papageorgiou E, Pitulis N, Msaouel P, Lembessis P, Koutsilieris M. The non-genomic crosstalk between PPAR-gamma ligands and ERK1/2 in cancer cell lines.- Expert Opin Ther Targets. 2007 Aug;11(8):1071-85.

Roberts PJ, Der CJ. Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer.- Oncogene. 2007 May 14;26(22):3291-310.

Meloche S, Pouysségur J. The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition.- Oncogene. 2007 May 14;26(22):3227-39.

McKay MM, Morrison DK. Integrating signals from RTKs to ERK/MAPK.- Oncogene. 2007 May 14;26(22):3113-21.

Mehdi MZ, Azar ZM, Srivastava AK. Role of receptor and nonreceptor protein tyrosine kinases in H2O2-induced PKB and ERK1/2 signaling.- Cell Biochem Biophys. 2007;47(1):1-10.

Zebisch A, Czernilofsky AP, Keri G, Smigelskaite J, Sill H, Troppmair J. Signaling through RAS-RAF-MEK-ERK: from basics to bedside.- Curr Med Chem. 2007;14(5):601-23.

Galabova-Kovacs G, Kolbus A, Matzen D, Meissl K, Piazzolla D, Rubiolo C, Steinitz K, Baccarini M. ERK and beyond: insights from B-Raf and Raf-1 conditional knockouts.-Cell Cycle. 2006 Jul;5(14):1514-8.

Ratto GM, Pizzorusso T.A kinase with a vision: Role of ERK in the synaptic plasticity of the visual cortex.-Adv Exp Med Biol. 2006;557:122-32.

Caunt CJ, Finch AR, Sedgley KR, McArdle CA.Seven-transmembrane receptor signalling and ERK compartmentalization.-Trends Endocrinol Metab. 2006 Sep;17(7):276-83.

Nishimoto S, Nishida E.MAPK signalling: ERK5 versus ERK1/2.-EMBO Rep. 2006 Aug;7(8):782-6.

Kohno M, Pouyssegur J.Targeting the ERK signaling pathway in cancer therapy.-Ann Med. 2006;38(3):200-11.

Torii S, Yamamoto T, Tsuchiya Y, Nishida E.ERK MAP kinase in G cell cycle progression and cancer.-Cancer Sci. 2006 Aug;97(8):697-702.

Werry TD, Christopoulos A, Sexton PM.Mechanisms of ERK1/2 regulation by seven-transmembrane-domain receptors.-Curr Pharm Des. 2006;12(14):1683-702.

Yoon S, Seger R.The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions. - Growth Factors. 2006 Mar;24(1):21-44.

McNamara N, Gallup M, Sucher A, Maltseva I, McKemy D, Basbaum C.AsialoGM1 and TLR5 cooperate in flagellin-induced nucleotide signaling to activate Erk1/2.-Am J Respir Cell Mol Biol. 2006 Jun;34(6):653-60.

Noon LA, Lloyd AC.Hijacking the ERK signaling pathway: Mycobacterium leprae shuns MEK to drive the proliferation of infected Schwann cells.-Sci STKE. 2005 Nov 8;2005(309):pe52.

Rubinfeld H, Seger R.The ERK cascade: a prototype of MAPK signaling.-Mol Biotechnol. 2005 Oct;31(2):151-74.

Meier F, Schittek B, Busch S, Garbe C, Smalley K, Satyamoorthy K, Li G, Herlyn M.The RAS/RAF/MEK/ERK and PI3K/AKT signaling pathways present molecular targets for the effective treatment of advanced melanoma.-Front Biosci. 2005 Sep 1;10:2986-3001.

Thompson N, Lyons J.Recent progress in targeting the Raf/MEK/ERK pathway with inhibitors in cancer drug discovery.-Curr Opin Pharmacol. 2005 Aug;5(4):350-6.

Harrisingh MC, Lloyd AC.Ras/Raf/ERK signalling and NF1.-Cell Cycle. 2004 Oct;3(10):1255-8.

Adjei AA.The role of mitogen-activated ERK-kinase inhibitors in lung cancer therapy.-Clin Lung Cancer. 2005 Nov;7(3):221-3.

Callaway K, Rainey MA, Dalby KN.Quantifying ERK2-protein interactions by fluorescence anisotropy: PEA-15 inhibits ERK2 by blocking the binding of DEJL domains..-Biochim Biophys Acta. 2005 Dec 30;1754(1-2):316-23.

Kolch W.Coordinating ERK/MAPK signalling through scaffolds and inhibitors.-Nat Rev Mol Cell Biol. 2005 Nov;6(11):827-37.

Rubinfeld H, Seger R.The ERK cascade: a prototype of MAPK signaling..-Mol Biotechnol. 2005 Oct;31(2):151-74.

Dumaz N, Marais R.Integrating signals between cAMP and the RAS/RAF/MEK/ERK signalling pathways. Based on the anniversary prize of the Gesellschaft fur Biochemie und Molekularbiologie Lecture delivered on 5 July 2003 at the Special FEBS Meeting in Brussels.-FEBS J. 2005 Jul;272(14):3491-504.

Torii S, Nakayama K, Yamamoto T, Nishida E.Regulatory mechanisms and function of ERK MAP kinases.-J Biochem (Tokyo). 2004 Nov;136(5):557-61.

Werry TD, Sexton PM, Christopoulos A."Ins and outs" of seven-transmembrane receptor signalling to ERK.-Trends Endocrinol Metab. 2005 Jan-Feb;16(1):26-33.

Viala E, Pouyssegur J.Regulation of tumor cell motility by ERK mitogen-activated protein kinases.-Ann N Y Acad Sci. 2004 Dec;1030:208-18.

Cheung EC, Slack RS.Emerging role for ERK as a key regulator of neuronal apoptosis.-Sci STKE. 2004 Sep 14;2004(251):PE45.

Williams SF, Smallridge RC.Targeting the ERK pathway: novel therapeutics for thyroid cancer.-Curr Drug Targets Immune Endocr Metabol Disord. 2004 Sep;4(3):199-220.

Oelke K, Richardson B.Decreased T cell ERK pathway signaling may contribute to the development of lupus through effects on DNA methylation and gene expression.-Int Rev Immunol. 2004 May-Aug;23(3-4):315-31.

Roux PP, Blenis J.ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions.-Microbiol Mol Biol Rev. 2004 Jun;68(2):320-44.

Chu CT, Levinthal DJ, Kulich SM, Chalovich EM, DeFranco DB.Oxidative neuronal injury. The dark side of ERK1/2.-Eur J Biochem. 2004 Jun;271(11):2060-6.

Ory S, Morrison DK.Signal transduction: implications for Ras-dependent ERK signaling.-Curr Biol. 2004 Apr 6;14(7):R277-8.

Houslay MD, Baillie GS.The role of ERK2 docking and phosphorylation of PDE4 cAMP phosphodiesterase isoforms in mediating cross-talk between the cAMP and ERK signalling pathways.-Biochem Soc Trans. 2003 Dec;31(Pt 6):1186-90.

Dong Z, Bode AM.Dialogue between ERKs and JNKs: friendly or antagonistic?-Mol Interv. 2003 Sep;3(6):306-8

Sasaki A, Taketomi T, Kato R, Saeki K, Nonami A, Sasaki M, Kuriyama M, Saito N, Shibuya M, Yoshimura A.Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1.-Cell Cycle. 2003 Jul-Aug;2(4):281-2

Waas WF, Rainey MA, Szafranska AE, Cox K, Dalby KN.A kinetic approach towards understanding substrate interactions and the catalytic mechanism of the serine/threonine protein kinase ERK2: identifying a potential regulatory role for divalent magnesium.-Biochim Biophys Acta. 2004 Mar 11;1697(1-2):81-7.

Rubinfeld H, Seger R. The ERK cascade as a prototype of MAPK signaling pathways.-Methods Mol Biol. 2004;250:1-28.

Colucci-D'Amato L, Perrone-Capano C, di Porzio U. Chronic activation of ERK and neurodegenerative diseases.-Bioessays. 2003 Nov;25(11):1085-95.

Steelman LS, Pohnert SC, Shelton JG, Franklin RA, Bertrand FE, McCubrey JA. JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis.-Leukemia. 2004 Feb;18(2):189-218.

Kohno M, Pouyssegur J. Pharmacological inhibitors of the ERK signaling pathway: application as anticancer drugs.-Prog Cell Cycle Res. 2003;5:219-24.

Sweatt JD, Weeber EJ. Genetics of childhood disorders: LII. Learning and memory, part 5: human cognitive disorders and the ras/ERK/CREB pathway.-J Am Acad Child Adolesc Psychiatry. 2003 Jul;42(7):873-6.

Chang F, Steelman LS, Lee JT, Shelton JG, Navolanic PM, Blalock WL, Franklin RA, McCubrey JA. Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention.-Leukemia. 2003 Jul;17(7):1263-93

Blanc A, Pandey NR, Srivastava AK. Synchronous activation of ERK 1/2, p38mapk and PKB/Akt signaling by H2O2 in vascular smooth muscle cells: potential involvement in vascular disease-Int J Mol Med. 2003 Feb;11(2):229-34

Smalley KS.A pivotal role for ERK in the oncogenic behaviour of malignant melanoma?-Int J Cancer. 2003 May 1;104(5):527-32

Hilger RA, Scheulen ME, Strumberg D.The Ras-Raf-MEK-ERK pathway in the treatment of cancer.-Onkologie. 2002 Dec;25(6):511-8

Chang F, Steelman LS, Shelton JG, Lee JT, Navolanic PM, Blalock WL, Franklin R, McCubrey JA.Regulation of cell cycle progression and apoptosis by the Ras/Raf/MEK/ERK pathway-Int J Oncol. 2003 Mar;22(3):469-80

Johnson GL, Lapadat R.Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases.-Science 2002 Dec 6;298(5600):1911-2

Andresen BT, Rizzo MA, Shome K, Romero G.The role of phosphatidic acid in the regulation of the Ras/MEK/Erk signaling cascade.-FEBS Lett. 2002 Oct 30;531(1):65-8

Pouyssegur J, Volmat V, Lenormand P.Fidelity and spatio-temporal control in MAP kinase (ERKs) signalling.-Biochem Pharmacol 2002 Sep;64(5-6):755-63

Katsanakis KD, Owen C, Zoumpourlis V.JNK and ERK signaling pathways in multistage mouse carcinogenesis: studies in the inhibition of signaling cascades as a means to understand their in vivo biological role.-Anticancer Res 2002 Mar-Apr;22(2A):755-9

Lee JT Jr, McCubrey JA.The Raf/MEK/ERK signal transduction cascade as a target for chemotherapeutic intervention in leukemia.-Leukemia 2002 Apr;16(4):486-507

Belcheva MM, Coscia CJ. Diversity of G protein-coupled receptor signaling pathways to ERK/MAP kinase.-Neurosignals 2002 Jan-Feb;11(1):34-44

Adams JP, Sweatt JD.Molecular psychology: roles for the ERK MAP kinase cascade in memory.-Annu Rev Pharmacol Toxicol 2002;42:135-63

Howe AK, Aplin AE, Juliano RL.Anchorage-dependent ERK signaling--mechanisms and consequences.-Curr Opin Genet Dev 2002 Feb;12(1):30-5

Peyssonnaux C, Eychene A.The Raf/MEK/ERK pathway: new concepts of activation.-Biol Cell 2001 Sep;93(1-2):53-62

Gudermann T.Multiple pathways of ERK activation by G protein-coupled receptors.-Novartis Found Symp 2001;239:68-79; discussion 80-4, 150-9

Kolch W.Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions.-Biochem J 2000 Oct 15;351 Pt 2:289-305

Kolch W.Curtis J, Finkbeiner S. Sending signals from the synapse to the nucleus: possible roles for CaMK, Ras/ERK, and SAPK pathways in the regulation of synaptic plasticity and neuronal growth.- J Neurosci Res 1999 Oct 1;58(1):88-95

Impey S, Obrietan K, Storm DR.Making new connections: role of ERK/MAP kinase signaling in neuronal plasticity.-Neuron 1999 May;23(1):11-4

Derkinderen P, Enslen H, Girault JA.The ERK/MAP-kinases cascade in the nervous system.-Neuroreport 1999 Apr 6;10(5):R24-34

Rane SG.Ion channels as physiological effectors for growth factor receptor and Ras/ERK signaling pathways.-Adv Second Messenger Phosphoprotein Res 1999;33:107-27

Kyriakis JM.Making the connection: coupling of stress-activated ERK/MAPK (extracellular-signal-regulated kinase/mitogen-activated protein kinase) core signalling modules to extracellular stimuli and biological responses.-Biochem Soc Symp 1999;64:29-48

Sugden PH, Clerk A.Regulation of the ERK subgroup of MAP kinase cascades through G protein-coupled receptors.-Cell Signal 1997 Aug;9(5):337-51

Marais R, Marshall CJ.Control of the ERK MAP kinase cascade by Ras and Raf.-Cancer Surv 1996;27:101-25

Cobb MH, Xu S, Cheng M, Ebert D, Robbins D, Goldsmith E, Robinson M.Structural analysis of the MAP kinase ERK2 and studies of MAP kinase regulatory pathways.-Adv Pharmacol 1996;36:49-65

Marshall CJ.Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. - Cell. 1995 Jan 27;80(2):179-85.

Cobb MH, Hepler JE, Cheng M, Robbins D.The mitogen-activated protein kinases, ERK1 and ERK2.-Semin Cancer Biol 1994 Aug;5(4):261-8

Robbins DJ, Zhen E, Cheng M, Xu S, Ebert D, Cobb MH.MAP kinases ERK1 and ERK2: pleiotropic enzymes in a ubiquitous signaling network.-Adv Cancer Res 1994;63:93-116

Crews CM, Alessandrini A, Erikson RL.Erks: their fifteen minutes has arrived.-Cell Growth Differ 1992 Feb;3(2):135-42

Cobb MH, Boulton TG, Robbins DJ.Extracellular signal-regulated kinases: ERKs in progress.-Cell Regul 1991 Dec;2(12):965-78

Cobb MH, Robbins DJ, Boulton TG.ERKs, extracellular signal-regulated MAP-2 kinases.-Curr Opin Cell Biol 1991 Dec;3(6):1025-32

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