Enterprise Lithuania MAP Kinase ResourceLSB2014

September 9


19:00: Welcome reception at Vilnius City (Town) Hall



September 10


09:15 - 09:25: Opening Speech by Jonas Cicenas

09:25 - 10:05: Plenary Session 1

Rony Seger, The Weizmann Institute of Science, Rehovot, Israel: “The Nuclear Translocation of MAPKs as a Drug Target for Signaling-Related Diseases”.

10:05 - 10:30: Coffee

10:30 - 11:15: The Invention of PCR.

Plenary by the Nobel Prize Laureate prof. Kary B. Mullis

11:25 - 13:00: Session 1

MAPK Kinase Bioinformatics and Computational Biology

Chair: Pascale Gaudet

11:25 - 11:50: Pascale Gaudet, Swiss Institute of Bioinformatics, Geneva, Switzerland: “NEXTPROT: a Knowledge Platform for Human Proteins”.

11:50 - 12:10: Jonas Cicenas, Swiss Institute of Bioinformatics and MAP Kinase Resource, Geneva, Switzerland: “MAP Kinase Resource – a Database and Knowledge Platform for MAPKs”.

12:10 - 12:30: Karthik Kalyan, Haffkine Institute and MAP Kinase Resource, Mumbai, India: “A Systems Biomedicine Approach Towards Modelling the MAP Kinase Pathways”.

12:30 - 12:50: Franziska Witzel, Charite Berlin, Germany: “Robustness of MAPK Signalling at Various Expression Levels of Erk1/2”.

12:50 - 14:00: Poster Session & Lunch

14:00 - 14:30: Session 2

Regulation of MAP Kinases

Chair: Jean-Francois Bodart

14:00 - 14:15: Keith Kirkwood, Medical University of South Carolina: “p38 MAPK/DUSP1 Axis in Stromal-mediated Tumorigenesis”.

14:15 - 14:30: Simon J. Cook, The Babraham Institute, Cambridge, UK: “Acquired Resistance to ERK1/2 Pathway Inhibitors in Tumour Cells; Pathway Adaptation and Associated Fitness Deficits”.

 14:30 - 15:30: Session 3

OMICS and MAP Kinases

Chair: Mindaugas Valius

14:30 - 14:50: Lee M. Graves, The University of North Carolina, Chapel Hill, USA: “Dynamic Reprogramming of the Kinome in Response to MEK and Other Kinase Inhibitors”.

14:50 - 15:10: Steven Pelech, Kinexus Bioinformatics Corporation, Vancouver, Canada: “Navigating Human Phosphorylation Networks With the SigNET Suite of On-line Knowledge Bases”.

15:10 - 15:30: Mindaugas Valius, Proteomics Centre, Vilnius, Lithuania: “Adaptor protein Nck in p120 RasGAP regulation

15:30 - 16:00: Poster Session & Coffee Break

16:00 - 16:55: Session 4

JNK Kinases

Chair: Rony Seger

16:00 - 16:20: Kanaga Sabapathy, National Cancer Center, Singapore: “A Sneak-Peek into Understanding the Functional Specificity of the C-Jun-Amino-Terminal Kinases”.

16:20 - 16:40: Tiziana Borsello, University Mario Negri, Milan, Italy: “JNK Mediates Synaptic Dysfunction Caused by A? Oligomers in Alzheimer Disease”.

16:40 - 16:55: Nomeda Girnius, University of Massachusetts Medical School, Worcester, Massachusetts: “Exploring the role of JNK in cancer and anoikis”.

 19:00: Gala Dinner at the Lithuanian National Opera and Ballet Theatre



September 11


08:40 - 10:00: Session 5

p38 Kinases

Chair: Romeo Ricci

08:40 - 09:00: Matthias Gaestel, Hannover Medical University, Hannover, Germany: “p38 MAPK and MK2/3 in Post-Transcriptional Regulation of Gene Expression”.

09:00 - 09:20: David Engelberg, The Hebrew University of Jerusalem, Jerusalem, Israel: “Novel Regulatory Mechanisms and Biological Functions of Hog1/p38s and Mpk1/ERKs Revealed by the Use of Constitutively Active Variants”.

09:20 - 09:40: Romeo Ricci, University of Strasbourg, France: “Non-Canonical p38 Signaling in Diabetes and Inflammation”.

09:40 - 10:00: Michael Courtney, University of Eastern Finland, Kuopio, Finland: “Regulation of p38MAPK in Excitotoxicity, a Common Mechanism of Neuronal Diseases”.

10:00 - 10:30: Poster Session & Coffee Break

10:30 - 11:50: Session 6

Raf-Erk Signaling

Chair: Steven Pelech

 10:30 - 10:50: Jean-Francois Bodart, Université des Sciences et Technologies de Lille, Villeneuve d'Ascq, France: “Challenging kinases activities within single cells”.

10:50 - 11:10: Antigone Lazou, Aristotle University of Thessaloniki, Greece: “MAPK/MSK1 Signaling in Cardiac Myocyte Stress Responses”.

11:10 - 11:30: Steven Pelech, Kinexus Bioinformatics Corporation, Vancouver, Canada: “Regulatory Roles of Conserved Phosphorylation Sites in the Activation T-Loop of the MAP Kinase ERK1”.

11:30 - 11:50: Karin Moelling, University of Zurich, Switzerland: “TBA”.

11:50 - 13:30: Session 7

MAP Kinases and Medicine

Chair: Anna Czarnecka

11:50 - 12:05: Anna Czarnecka, Military Institute of Medicine, Warsaw, Poland: “MAP kinases and renal cell carcinoma - friends or foes”?

12:05 - 12:20: Daiva Bironaite, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania: “Protection of Myogenic Stem Cells by Heat Shock-Induced Hsp70. Involvement of MAPKs”.

12:20 - 12:35: Li Xing, Pfizer, Cambridge, USA: “Structural Bioinformatics Analysis Predicts Superior Kinome Selectivity of Clinical p38 MAPK Inhibitor”.

12:35 - 13:30: Poster Session & Lunch

13:30 - 15:00: Session 8

MAP Kinases in Diverse Biological Systems

Chair: Jokubas Ziburkus

13:30 - 13:50: Jokubas Ziburkus, University of Houston, USA: “Modulation of MAP kinase signaling cascades in neurological disorders”.

13:50 - 14:10: Irute Meskiene, University of Vienna, Austria and Institute of Biotechnology, Vilnius, Lithuania: “Control of MAPK Signaling by PP2C-Type MAPK Phosphatases in Arabidopsis”. CANCELLED

14:10 - 14:30: Eleanor Coffey, Turku University, Finland: “Cytosolic JNK substrates and their function in brain”. CANCELLED

14:30 - 14:45: Hesso Farhan, Biotechnology Institute Thurgau, Switzerland: “Regulation of ERK1/2 by the pseudophosphatase STYX: implications for cell migration and epithelial-mesenchymal transition”.

14:45 - 15:00: John Brognard, The University of Manchester, UK: “Mixed Lineage Kinases (MLKs): Novel Mediators of Resistance to Targeted Therapies and MLK4 is a Novel Tumor Suppressor in Colon Cancer”.

15:00 - 15:30: Poster Session & Coffee Break

15:30 - 16:10: Plenary Session 2

Tony Hunter, Salk Institute for Biological Studies, La Jolla, USA: “Regulation of cell signaling by post-translational modification of proteins”.

16:10 - 16:40: Finishing Remarks and Poster Awards

19:00: Lithuanian Reception at U┼żutrakis Manor House