The mission of The MAP Kinase Resource is to collect the information about MAP kinases, shear it with a scientific community, students and all other interested. We would also like to improve communications between medical and life science professionals who are interested in MAPkinases.

The MAP Kinase Resource Website was created in 1998. The inspiration at the time came from other specialized websites, such as websites on receptors, transcription factors, etc.

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MAP Kinase Journal

“MAP Kinase” is the first journal to concentrate specifically on the Mitogen-activating protein kinase family of protein kinases. MAP kinases are serine/threonine protein kinases that respond to extracellular stimuli and regulate various cellular activities, such as apoptosis, gene expression, mitosis, differentiation and immune responses, to name just a few. The MAP kinase family consists of four major subfamilies of related proteins (Erk1/2, JNK, p38 and Erk5) that make up interconnected signal transduction cascades activated by external stimuli, such as growth factors, stress, cytokines and inflammation...

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MAPK Resource

MAP Kinase Resource website is a MAP kinase database, based on NCBI protein sequences. Here you can find the sequences of all MAP kinases in different species. This database will be constantly renewed and your input is especially welcome!

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Researchers

Researchers – the database of scientists interested in MAP kinases. If your are looking for a potential collaborator, employer or a person who could answer your questions, share a plasmid or an antibody with you, this is the right place for you. Moreover, if you had published at least one paper in MAP kinase field, you are welcome to add yourself to the list!

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ERK1/2

The ERKs (MAPK p42/p44) are the prototypic MAPKs and are activated by a variety of mitogenic stimuli as well as differentiation signals. MAPK activation largely requires Ras activation. In Drosophila, the ERK homologue is encoded by the Rolled locus (an activated allele) which has been placed downstream of Ras in the sevenless receptor kinase pathway.

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Protocols

Protocols – need a help with an assay? Have a looke here, maybe you will find what you are looking for. The founder of MAP Kinase Resource is sharing his experience on stuff he knows to work!

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Nomenclature

Probably the hardest thing in Cell Signaling research is the fact, that most of the molecules have many alternative names. It is sometimes hard to figure out, which kinase people are talking about if one doesn`t know the alternative names. You will find a list of all possible alternative names of mammalian MAP kinases.

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Plasmid donations

MAP Kinase Research invites all scientists to donate their MAP kinase constructs in any vectors. We are trying to create a database of MAP kinase constructs (wild type genes, mutants, tagged constructs etc.) for the use of all scientific community. All those, who are willing to send their constructs,

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Community

If you are interested in MAP kinases, you are definitely not alone! The forum should help us come together and discuss any aspects of MAP kinase research. We can discuss protocols, papers, hypotheses and any other aspect of MAPKs. We can even share hobbies or jokes!

Anyone is welcome to join